BiTud

Chemical Structure : BiTud

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货号: PC-21575Not For Human Use, Lab Use Only.

BiTud is a bivalent inhibitor against TDRD3 with binding Kd of 6 uM for tandem Tudor chimera, blocks the recruitment of TDRD3 by the two methylated arginines of G3BP1, suppress the phase separation of methylated G3BP1, TDRD3, and RNAs, and in turn inhibits the stress granule growth in cells.

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生物&药学活性

BiTud is a bivalent inhibitor against TDRD3 with binding Kd of 6 uM for tandem Tudor chimera, blocks the recruitment of TDRD3 by the two methylated arginines of G3BP1, suppress the phase separation of methylated G3BP1, TDRD3, and RNAs, and in turn inhibits the stress granule growth in cells.
BiTud directly disrupts the multivalent interaction between the SG hub protein G3BP1 and its ADMA readers.
BiTud exhibits inhibitory efficacy in the SG growth and sensitizes U2OS cells to arsenite treatment.

物理化学性质&存储条件

分子量	641.55
分子式	C28H38Cl2N6O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(1-(4-chloro-2-nitrophenyl)piperazine)

参考文献

1. Fan WW, et al. Chem Commun (Camb). 2023 Dec 21. doi: 10.1039/d3cc04654k.

2. Patent CN113943264 A.

BiTud

生物&药学活性

物理化学性质&存储条件

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BiTud

生物&药学活性

物理化学性质&存储条件

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