Bezisterim (HE3286, NE3107)

Chemical Structure : Bezisterim

CAS No.: 1001100-69-1

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货号: PC-21972Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Bezisterim (HE3286, NE3107) is an orally bioavailable synthetic analogue of an active DHEA metabolite, displays both glucose-lowering and cholesterol-lowering effects, inhibits inflammatory NF-κB transcription, and confers oral bioavailability and blood-brain barrier permeability.
Bezisterim (HE3286) attenuates LPS- and TNFalpha-stimulated inflammation in primary murine macrophages.
Bezisterim (HE3286) downregulates inflammatory cytokine/chemokine expression in liver and adipose tissue of Zucker diabetic fatty rats.

物理化学性质&存储条件

分子量	330.47
分子式	C21H30O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	17alpha-pregn-5-en-20-yne-3beta,7beta,17-triol

参考文献

1. Kosiewicz MM, et al. Eur J Pharmacol. 2011 May 11;658(2-3):257-62.

2. Wang T, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):70-80.

3. Offner H, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1100-9.