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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-Bexagliflozin
Bexagliflozin

Chemical Structure : Bexagliflozin

CAS No.: 1118567-05-7

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Bexagliflozin (THR-1442, EGT1442)

货号: PC-45385Not For Human Use, Lab Use Only.

Bexagliflozin (THR-1442, EGT1442) is a potent and selective SGLT2 inhibitor with IC50 of 2 nM.

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10 mg ￥2280 In stock
25 mg ￥3780 In stock
50 mg ￥5780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bexagliflozin (THR-1442, EGT1442) is a potent and selective SGLT2 inhibitor with IC50 of 2 nM.
Bexagliflozin shows little activity for SGLT1 (IC50=5.6 uM).
Bexagliflozin produces a saturable urinary glucose excretion in normal rats and dogs with ED50 of 0.38 and 0.09mg/kg, respectively.
Bexagliflozin reduced HbA(1c) and blood glucose concentration without affecting body mass or insulin level in db/db mice.

物理化学性质&存储条件

分子量 464.9359
分子式 C24H29ClO7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)-

参考文献

1. Wang L, et al. Xenobiotica. 2016 Aug;46(8):703-8.

2. Zhang W, et al. Pharmacol Res. 2011 Apr;63(4):284-93.

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