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首页-小分子抑制剂&激动剂-Others-Other Targets-Betulin
Betulin

Chemical Structure : Betulin

CAS No.: 473-98-3

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Betulin (NSC 4644)

货号: PC-20459Not For Human Use, Lab Use Only.

Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig.

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100 mg ￥1980 In stock
200 mg ￥2880 In stock
500 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig.
Betulin binds to SREBP cleavage activating protein (SCAP), stimulates the interaction between SCAP and Insig, blocks the maturation of SREBPs
Betulin specifically inhibits the SREBP processing but does not activate LXR or accelerate HMGCR degradation.
Betulin downregulates SREBP target genes and decreases cellular lipid levels, including HMGCR, HMG-CoA synthase (HMGCS), and squalene epoxidase (SE), SREBP-1c, fatty acid synthase (FAS), and acetyl-Co A carboxylase alpha (ACC).
Betulin decreased the lipid levels in serum and tissues and increased insulin sensitivity in western-type diet ingested mice. 
Betulin reduced the size and improved the stability of atherosclerotic plaques in atherosclerosis disease model, LDLR-knockout mice.

物理化学性质&存储条件

分子量 442.73
分子式 C30H50O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol

参考文献

1. Tang JJ, et al. Cell Metab. 2011 Jan 5;13(1):44-56.

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