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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Factor Xa-Betrixaban
Betrixaban

Chemical Structure : Betrixaban

CAS No.: 330942-05-7

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Betrixaban (PRT-054021;PRT 054021;PRT054021)

货号: PC-42505Not For Human Use, Lab Use Only.

A highly potent, selective Factor Xa inhibitor with Ki/IC50 of 0.117 nM/1.5 nM.

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10 mg ￥1120 In stock
50 mg ￥2560 In stock
100 mg ￥4400 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A highly potent, selective Factor Xa inhibitor with Ki/IC50 of 0.117 nM/1.5 nM; no significant activity against thrombin, plasmin, tPA, activated protein C, and kallikrein; exhibts weak binding affinity for hERG (Ki=0.42 uM); orally efficacious.

Thrombosis

Phase 3 Clinical

物理化学性质&存储条件

分子量 451.9055
分子式 C23H22ClN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 22 mg/mL
Chemical Name/SMILES

Benzamide, N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-

参考文献

1. Zhang P, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2179-85.

2. Cohen AT, et al. Am Heart J. 2014 Mar;167(3):335-41.

3. Cohen AT, et al. N Engl J Med. 2016 Aug 11;375(6):534-44.

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