Bersiporocin (DWN12088)

Chemical Structure : Bersiporocin

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货号: PC-73404Not For Human Use, Lab Use Only.

Bersiporocin (DWN 12088) is an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor with antifibrotic effect.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Bersiporocin (DWN 12088) is a first-in-class, orally active small molecule prolyl-tRNA synthetase (PRS) inhibitor with antifibrotic effect.
Prolyl-tRNA synthetase (PRS) is an enzyme that conjugates proline to tRNA, which is an essential process in protein translation.
Bersiporocin (DWN 12088) inhibited collagen and αSMA in human dermal fibroblast.
Bersiporocin (DWN 12088) significantly reduced skin thickness and collagen amount in dose-dependent manner bleomycin (BLM)-induced mouse pulmonary fibrosis model.
Bersiporocin (DWN 12088) increased collagen deposition and significantly impaired lung function in the BLM-induced mouse skin fibrosis model lung.

物理化学性质&存储条件

分子量	328.237
分子式	C15H19Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S)-2-[3-(4,5-Dichloro-1H-benzimidazol-1-yl)propyl]-3-piperidinol

参考文献

1. Caroline Lee, et al. European Respiratory Journal 2021 58: OA4241.