Bersacapavir (JNJ 56136379) | HBV capsid inhibitor | Probechem Biochemicals

Chemical Structure : Bersacapavir

CAS No.: 1638266-40-6

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Bersacapavir (JNJ 56136379, JNJ-6379)

货号: PC-20253Not For Human Use, Lab Use Only.

Bersacapavir (JNJ 56136379, JNJ-6379) is a potent HBV capsid assembly modulator, JNJ-6379 specifically and potently inhibits HBV replication with EC50 of 54 nM (HepG2.117 cells).

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10 mg	￥3980	In stock
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生物&药学活性

Bersacapavir (JNJ 56136379, JNJ-6379) is a potent HBV capsid assembly modulator, JNJ-6379 specifically and potently inhibits HBV replication with EC50 of 54 nM (HepG2.117 cells).
Bersacapavir (JNJ 56136379, JNJ-6379) dose-dependently reduced extracellular HBV DNA levels (median EC50 of 93 nM) and prevented covalently closed circular DNA (cccDNA) formation.
Bersacapavir (JNJ 56136379, JNJ-6379) reduced intracellular HBV RNA levels (median EC50 of 876 nM) and reduced antigen levels in HBV-infected primary human hepatocytes (PHHs).

物理化学性质&存储条件

分子量	418.37
分子式	C16H14F4N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-cyano-4-fluorophenyl)-1-methyl-4-(N-(1,1,1-trifluoropropan-2-yl)sulfamoyl)-1H-pyrrole-2-carboxamide

参考文献

1. Berke JM, et al. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02439-19.

2. Zoulim F, et al. Gastroenterology. 2020 Aug;159(2):521-533.e9.

Bersacapavir (JNJ 56136379, JNJ-6379)

生物&药学活性

物理化学性质&存储条件

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Bersacapavir (JNJ 56136379, JNJ-6379)

生物&药学活性

物理化学性质&存储条件

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