Berotralstat |CAS:1809010-50-1 Probechem Biochemicals

Chemical Structure : Berotralstat

CAS No.: 1809010-50-1

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Berotralstat (BCX7353, BCX-7353)

货号: PC-36087Not For Human Use, Lab Use Only.

Berotralstat (BCX7353, BCX-7353) is a potent, highly selective, oral plasma kallikrein inhibitor.

规格	价格	库存
2 mg	￥2280	In stock
5 mg	￥3680	In stock
10 mg	￥5880	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Berotralstat (BCX7353, BCX-7353) is a potent, highly selective, oral plasma kallikrein inhibitor.

Berotralstat (BCX7353) displays high selectivity over other structurally related serine proteases.

Berotralstat (BCX7353) is the first orally bioavailable prophylactic treatment for hereditary angioedema (HAE) attacks.

物理化学性质&存储条件

分子量	562.573
分子式	C30H26F4N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[3-(aminomethyl)phenyl]-N-(5-{(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

参考文献

1, Kotian PL, et al. J Med Chem. 2021 Sep 9;64(17):12453-12468.
2, Aygören-Pürsün E, et al. N Engl J Med. 2018 Jul 26;379(4):352-362.
3, Farkas H, et al. Clin Transl Allergy. 2021 Jun;11(4):e12035.
4, Zuraw B, et al. J Allergy Clin Immunol. 2021 Jul;148(1):164-172.e9.

Berotralstat (BCX7353, BCX-7353)

生物&药学活性

物理化学性质&存储条件

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Berotralstat (BCX7353, BCX-7353)

生物&药学活性

物理化学性质&存储条件

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