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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-Bergamottin
Bergamottin

Chemical Structure : Bergamottin

CAS No.: 7380-40-7

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Bergamottin (5-Geranoxypsoralen, Bergamotine, Bergaptin)

货号: PC-27657Not For Human Use, Lab Use Only.

Bergamottin (5-Geranoxypsoralen, Bergamotine) is a bioactive component of bergamot and a competitive inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki of 10.7 nM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bergamottin (5-Geranoxypsoralen, Bergamotine) is a bioactive component of bergamot and a competitive inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki of 10.7 nM.
Bergamottin ameliorates the progression of osteoarthritis via the Sirt1/NF-kappaB pathway.
Bergamottin inhibits porcine reproductive and respiratory syndrome virus (PRRSV), blocks expression of the non-structural proteins (Nsps), leading to the interruption of replication and transcription complex (RTC) formation and viral dsRNA synthesis.
Bergamottin exhibits inhibitory activity against SARS-CoV-2 in vitro, ex vivo, and in vivo, interferes with multiple stages of virus life cycles, specifically blocking the SARS-CoV-2 spike-mediated membrane fusion and effectively reducing viral RNA synthesis.

物理化学性质&存储条件

分子量 338.40
分子式 C21H22O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-4-((3,7-Dimethylocta-2,6-dien-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one

参考文献

1. Olguín-Reyes S, et al. Food Chem Toxicol. 2012 Sep;50(9):3094-9.

2. Baumgart A, et al. Biochem Pharmacol. 2005 Feb 15;69(4):657-67.

3. Qiao RB, et al. Chin J Traumatol. 2024 Sep;27(5):295-304.

4. Zhou M, et al. Antiviral Res. 2022 Aug;204:105365.

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