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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-Berberine
Berberine

Chemical Structure : Berberine

CAS No.: 2086-83-1

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Berberine (Natural Yellow 18)

货号: PC-26655Not For Human Use, Lab Use Only.

Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation

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500 mg ￥780 In stock
1 g ￥1180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.

物理化学性质&存储条件

分子量 336.37
分子式 C20H18NO4+
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium

参考文献

1. Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68(1):53-62.

2. Wang Y, et al. Nucleic Acids Res. 2026 May 5;54(9):gkag383.

3. Gang Xu, et al. Phytomedicine. 2026 Mar:152:157765.

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