Benvitimod | AhR agonist | Probechem Biochemicals

Chemical Structure : Benvitimod

CAS No.: 79338-84-4

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Benvitimod (WBI-1001, WB-1001, GSK-2894512, Tapinarof)

货号: PC-60054Not For Human Use, Lab Use Only.

Benvitimod (GSK-2894512, Tapinarof) is a natural aryl hydrocarbon receptor (AhR) agonist with anti-inflammatory properties.

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生物&药学活性

Benvitimod (GSK-2894512, Tapinarof) is a natural aryl hydrocarbon receptor (AhR) agonist with anti-inflammatory properties.
Benvitimod binds and activates AhR in multiple cell types, moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes.
Benvitimod shows no impact on imiquimod-induced skin inflammation in AhR-deficient mice.

物理化学性质&存储条件

分子量	254.329
分子式	C17H18O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-Dihydroxy-4-isopropylstilbene

参考文献

1. Bissonnette R, et al. Arch Dermatol. 2010 Apr;146(4):446-9.

2. Bissonnette R, et al. J Eur Acad Dermatol Venereol. 2012 Dec;26(12):1516-21.

3. Smith SH,et al. J Invest Dermatol. 2017 Oct;137(10):2110-2119.

Benvitimod (WBI-1001, WB-1001, GSK-2894512, Tapinarof)

生物&药学活性

物理化学性质&存储条件

参考文献

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Benvitimod (WBI-1001, WB-1001, GSK-2894512, Tapinarof)

生物&药学活性

物理化学性质&存储条件

参考文献

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