Bemnifosbuvir | HCV inhibitor | Probechem Biochemicals

Chemical Structure : Bemnifosbuvir

CAS No.: 1998705-64-8

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Bemnifosbuvir (AT-527, AT527)

货号: PC-22912Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Bemnifosbuvir (AT-527, RG-6422) is a novel phosphoramidate prodrug of AT-511 that has potent in vitro activity against HCV (EC50=5-28 nM), also inhibits replication of SARS-CoV-2 with EC90 of 0.47 uM.
AT-527 shows similar potency against human coronavirus (HCoV)-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells, with little to no cytotoxicity was observed for AT-511 at concentrations up to 100 uM.
Once in cells, AT-527 is converted into its triphosphate form, AT-9010, that presumably targets the viral RNA-dependent RNA polymerase (RdRp, nsp12), for incorporation into viral RNA.
AT-9010 outcompetes all native nucleotides for NiRAN binding, inhibiting its nucleotidyltransferase activity.

物理化学性质&存储条件

分子量	581.54
分子式	C24H33FN7O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

参考文献

1. Good SS, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.

2. Do TND, et al. Antiviral Res. 2021 Aug;192:105122.

Bemnifosbuvir (AT-527, AT527)

生物&药学活性

物理化学性质&存储条件

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Bemnifosbuvir (AT-527, AT527)

生物&药学活性

物理化学性质&存储条件

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