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首页-抗体和重组蛋白-Biosimilar Antibody-Belrestotug
Belrestotug

Chemical Structure : Belrestotug

CAS No.: 2574438-65-4

Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A)

货号: PC-49122Not For Human Use, Lab Use Only.

Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A) is a fully human IgG1 TIGIT antagonist monoclonal antibody, fully prevents CD155-mediated inhibition.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A) is a fully human IgG1 TIGIT antagonist monoclonal antibody, fully prevents CD155-mediated inhibition.
EOS-448 does not cross-react with mouse TIGIT, the anti-TIGIT antibody used in murine models is a surrogate antibody produced at UProtein.
EOS-448 prevents CD155 binding and increases the functional activity of TIGIT+ cells, blocks TIGIT restored secretion of IFNγ in a dose-dependent manner on CD8+ T cells from healthy donor PBMCs activated in the presence of CD155-expressing cells, also boosts the functional activity of T cells in samples from solid tumor patients.
EOS-448 induces preferential depletion of Tregs,triggers preferential antibody-dependent lysis of Tregs ex vivo.

Isotype: IgG1-kappa.
Anti-[human TIGIT (T-cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

参考文献

1. Julie Preillon, et al. Mol Cancer Ther. 2021 Jan;20(1):121-131.

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