Belrestotug | Anti-TIGIT | Probechem Biochemicals

Chemical Structure : Belrestotug

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Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A)

货号: PC-49122Not For Human Use, Lab Use Only.

Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A) is a fully human IgG1 TIGIT antagonist monoclonal antibody, fully prevents CD155-mediated inhibition.

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生物&药学活性

Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A) is a fully human IgG1 TIGIT antagonist monoclonal antibody, fully prevents CD155-mediated inhibition.
EOS-448 does not cross-react with mouse TIGIT, the anti-TIGIT antibody used in murine models is a surrogate antibody produced at UProtein.
EOS-448 prevents CD155 binding and increases the functional activity of TIGIT+ cells, blocks TIGIT restored secretion of IFNγ in a dose-dependent manner on CD8+ T cells from healthy donor PBMCs activated in the presence of CD155-expressing cells, also boosts the functional activity of T cells in samples from solid tumor patients.
EOS-448 induces preferential depletion of Tregs,triggers preferential antibody-dependent lysis of Tregs ex vivo.

Isotype: IgG1-kappa.
Anti-[human TIGIT (T-cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Julie Preillon, et al. Mol Cancer Ther. 2021 Jan;20(1):121-131.

Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A)

生物&药学活性

物理化学性质&存储条件

参考文献

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Belrestotug (EOS-448, EOS 884448, GSK 4428859, GSK 4428859A)

生物&药学活性

物理化学性质&存储条件

参考文献

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