Beloranib |CAS:251111-30-5 Probechem Biochemicals

Chemical Structure : Beloranib

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Beloranib (CKD-732; ZGN-440)

货号: PC-61441Not For Human Use, Lab Use Only.

Beloranib (ZGN-440) is an analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.

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生物&药学活性

Beloranib (ZGN-440) is an analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.
Beloranib (ZGN-440) strongly inhibit the growth of cancers in xenografted nude model.
Beloranib (ZGN-440) also causes significant body weight and appetite reduction an anti-obesity agent.

物理化学性质&存储条件

分子量	499.65
分子式	C29H41NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(3R,6R,7S,8S)-7-methoxy-8-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate

参考文献

1. Kim YM, et al. J Mol Endocrinol. 2007 Apr;38(4):455-65.

2. Morgen M, et al. ACS Chem Biol. 2016 Apr 15;11(4):1001-11.

3. Chun E, et al. Int J Cancer. 2005 Mar 10;114(1):124-30.

4. Hughes TE, et al. Obesity (Silver Spring). 2013 Sep;21(9):1782-8.

Beloranib (CKD-732; ZGN-440)

生物&药学活性

物理化学性质&存储条件

参考文献

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Beloranib (CKD-732; ZGN-440)

生物&药学活性

物理化学性质&存储条件

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