Befiradol (F13640, NLX-112) | 5-HT1A agonist | Probechem Biochemicals

Chemical Structure : Befiradol

CAS No.: 208110-64-9

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Befiradol (F 13640, NLX-112)

货号: PC-61625Not For Human Use, Lab Use Only.

Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Befiradol (F13640, NLX-112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
Befiradol (F13640, NLX 112) exhibits agonist efficacy greater than for (±)8-OH-DPAT or buspirone.
Befiradol (F13640, NLX 112) stimulates 'total G-proteins', but unlike (±)8-OH-DPAT and buspirone, more potent for Gαo activation, in rat hippocampal membranes.
Befiradol (F13640, NLX 112) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC in rats, activates both 5-HT(1A) autoreceptors and postsynaptic 5-HT(1A) receptors in prefrontal cortex with a similar potency.

物理化学性质&存储条件

分子量	393.857
分子式	C20H22ClF2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone

参考文献

1. Bollinger S, et al. J Med Chem. 2010 Oct 14;53(19):7167-79.

2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72.

3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.

Befiradol (F 13640, NLX-112)

生物&药学活性

物理化学性质&存储条件

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Befiradol (F 13640, NLX-112)

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物理化学性质&存储条件

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