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Bedaquiline

Chemical Structure : Bedaquiline

CAS No.: 843663-66-1

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Bedaquiline (TMC207, R207910)

货号: PC-23456Not For Human Use, Lab Use Only.

Bedaquiline fumarate (TMC207, R207910) is a diarylquinoline antibiotic that targets ATP synthase, inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bedaquiline fumarate (TMC207, R207910) is a diarylquinoline antibiotic that targets ATP synthase, inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit.
Bedaquiline is effective for the treatment of Mycobacterium tuberculosis infections.

物理化学性质&存储条件

分子量 484.73
分子式 C37H40
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

参考文献

1. Jang JC, et al. J Microbiol. 2017 Apr 20.

2. Pang Y, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5).

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