Beclabuvir | HCV NS5B inhibitor | Probechem Biochemicals

Chemical Structure : Beclabuvir

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Beclabuvir (BMS791325, BMS-791325)

货号: PC-63571Not For Human Use, Lab Use Only.

Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.

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生物&药学活性

Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
Beclabuvir inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of <30 nM.
The combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1 in clinical trials.

物理化学性质&存储条件

分子量	659.846
分子式	C36H45N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide

参考文献

1. Gentles RG, et al. J Med Chem. 2014 Mar 13;57(5):1855-79.

2. Sims KD, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503.

3. Everson GT, et al. Gastroenterology. 2014 Feb;146(2):420-9.

4. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9.

Beclabuvir (BMS791325, BMS-791325)

生物&药学活性

物理化学性质&存储条件

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Beclabuvir (BMS791325, BMS-791325)

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物理化学性质&存储条件

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