BeKm-1 |CAS:524962-01-4 Probechem Biochemicals

Chemical Structure : BeKm-1

CAS No.: 524962-01-4

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BeKm-1 (BeKm 1)

货号: PC-60837Not For Human Use, Lab Use Only.

BeKm-1 is a potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels.

规格	价格	库存
100 ug	￥2980	In stock
500 ug	￥5980	In stock
1 mg	￥8980	In stock
5 mg		Get quote
10 mg		Get quote

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生物&药学活性

BeKm-1 is a potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels.
BeKm-1 displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1.
BeKm-1 prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively).

物理化学性质&存储条件

分子量	4091.65
分子式	C174H261N51O52S6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	RPTDIKCSESYQCFPVCKSRFGKTNGRCVNGFCDCF (Modifications: Disulfide bridge: 7-28,13-33,17-35)

参考文献

1. Korolkova YV, et al. J Biol Chem. 2002 Nov 8;277(45):43104-9.

2. Korolkova YV, et al. J Biol Chem. 2001 Mar 30;276(13):9868-76.

3. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8.

4. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8.

BeKm-1 (BeKm 1)

生物&药学活性

物理化学性质&存储条件

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BeKm-1 (BeKm 1)

生物&药学活性

物理化学性质&存储条件

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