Baxdrostat (CIN-107, RO6836191) | CYP11 B2 inhibitor | Probechem Biochemicals

Chemical Structure : Baxdrostat

CAS No.: 1428652-17-8

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Baxdrostat (CIN-107, CIN107, RO6836191)

货号: PC-38384Not For Human Use, Lab Use Only.

Baxdrostat (CIN-107, RO6836191) is a highly potent, selective, and competitive small molecule inhibitor of aldosterone synthase (CYP11 B2, steroid 18-hydroxylase) with Ki of 13 nM, >100-fold over 11β-hydroxylase.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Baxdrostat (CIN-107, RO6836191) is a highly potent, selective, and competitive small molecule inhibitor of aldosterone synthase (CYP11 B2, steroid 18-hydroxylase) with Ki of 13 nM, >100-fold over 11β-hydroxylase.
Baxdrostat (CIN-107, RO6836191) inhibited aldosterone synthesis without affecting the adrenocorticotropic hormone–induced rise in cortisol.
Baxdrostat (CIN-107, RO6836191) suppresses aldosterone production completely in humans without affecting cortisol production.

物理化学性质&存储条件

分子量	363.461
分子式	C22H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide

参考文献

1. Bogman K, Schwab D, Delporte ML, Palermo G, Amrein K, Mohr S, et al. Preclinical and early clinical profile of a highly selective and potent oral inhibitor of aldosterone synthase (CYP11B2). Hypertension. 2017;69:189–96.

Baxdrostat (CIN-107, CIN107, RO6836191)

生物&药学活性

物理化学性质&存储条件

参考文献

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Baxdrostat (CIN-107, CIN107, RO6836191)

生物&药学活性

物理化学性质&存储条件

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