Batiraxcept | AXL Fc fusion | Probechem Biochemicals

Chemical Structure : Batiraxcept

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Batiraxcept (AVB-S6-500, AVB-500)

货号: PC-38856Not For Human Use, Lab Use Only.

Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.

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生物&药学活性

Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.
Batiraxcept (AVB‐S6‐500, AVB-500) neutralized growth arrest-specific 6 (GAS6) protein and effectively inhibited AXL signaling in preclinical cancer models.
ABatiraxcept (AVB‐S6‐500, AVB-500) binds GAS6 with low femtomolar range affinity to effectively bind GAS6 and eliminate its ability to stimulate the AXL pathway.
Human tyrosine-protein kinase receptor UFO (AXL oncogene) fragment (8-202, 1-195 in the current sequence), variant (G14>S7, A54>V47, D69>G62, V74>A67, G109>R102), fused via peptidyl linker (196GGGGS200) to a human immunoglobulin G1 Fc fragment (201-426, C-terminal Lys residue deleted), dimer, glycosylated, produced in Chinese hamster ovary (CHO) cells.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Bonifacio L, et al. Clin Transl Sci. 2020 Jan;13(1):204-211.

2. Mullen MM, et al. Mol Cancer Res. 2022 Feb;20(2):265-279.

Batiraxcept (AVB-S6-500, AVB-500)

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物理化学性质&存储条件

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Batiraxcept (AVB-S6-500, AVB-500)

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物理化学性质&存储条件

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