Basmisanil | GABAA α5 NAM | Probechem Biochemicals

Chemical Structure : Basmisanil

CAS No.: 1159600-41-5

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Basmisanil (RG1662, RO5186582)

货号: PC-45060Not For Human Use, Lab Use Only.

Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Basmisanil (RG1662) is a potent, selective negative allosteric modulator of GABAA receptor α5-subtype with binding Ki of 5 nM for recombinant human GABAA-α5 receptors.
Basmisanil (RG1662) displays >90-fold selectivity versus α1, α2, and α3 subunit-containing receptors.
Basmisanil (RG1662) inhibits GABA-induced currents at GABAA-α5, yet has little or no effect at the other receptor subtypes.
Basmisanil (RG1662) attenuated diazepam-induced spatial learning impairment in rats (Morris water maze), improved executive function in non-human primates (object retrieval), without showing anxiogenic or proconvulsant effects in rats.

物理化学性质&存储条件

分子量	445.464
分子式	C21H20FN3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Methanone, (1,1-dioxido-4-thiomorpholinyl)[6-[[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-

参考文献

1. Myers JF, et al. J Cereb Blood Flow Metab. 2017 Jun;37(6):2137-2148.

2. Costa AC, et al. CNS Drugs. 2013 Sep;27(9):679-702.

Basmisanil (RG1662, RO5186582)

生物&药学活性

物理化学性质&存储条件

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Basmisanil (RG1662, RO5186582)

生物&药学活性

物理化学性质&存储条件

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