Bardoxolone methyl (CDDO-Me, RTA402) | Nrf2 activator

Chemical Structure : Bardoxolone methyl

CAS No.: 218600-53-4

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Bardoxolone methyl (CDDO-Me, RTA402, NSC 713200)

货号: PC-43494Not For Human Use, Lab Use Only.

Bardoxolone methyl (CDDO-Me, RTA402) is a potent activator of Nrf2, inhibits proliferation, induces differentiation and apoptosis in AML cells.

规格	价格	库存
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg	￥1980	In stock
1 g		Get quote

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生物&药学活性

Bardoxolone methyl (CDDO-Me, RTA402) is a potent activator of Nrf2, inhibits proliferation, induces differentiation and apoptosis in AML cells.
CDDO Methyl ester induces rapid apoptosis (IC50=0.1-0.3 uM) and triggers a series of effects associated with apoptosis including a rapid release of cytochrome c from mitochondria, activation of procaspase-9, -7, -6, and -3, and cleavage of PARP and lamin A/C in NSCLC cells.
CDDO Methyl ester also demonstrates potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice.

物理化学性质&存储条件

分子量	505.69
分子式	C32H43NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 49 mg/mL
Chemical Name/SMILES	Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester

参考文献

1. Konopleva M, et al. Blood. 2002 Jan 1;99(1):326-35.

2. Kim KB, et al. Mol Cancer Ther. 2002 Jan;1(3):177-84.

3. Thimmulappa RK, et al. Antioxid Redox Signal. 2007 Nov;9(11):1963-70.

4. Yates MS, et al. Mol Cancer Ther. 2007 Jan;6(1):154-62.

Bardoxolone methyl (CDDO-Me, RTA402, NSC 713200)

生物&药学活性

物理化学性质&存储条件

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Bardoxolone methyl (CDDO-Me, RTA402, NSC 713200)

生物&药学活性

物理化学性质&存储条件

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