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首页-抗体和重组蛋白-Biosimilar Antibody-Bapotulimab
Bapotulimab

Chemical Structure : Bapotulimab

CAS No.: 2359413-58-2

Bapotulimab (BAY1905254)

货号: PC-38854Not For Human Use, Lab Use Only.

Bapotulimab (BAY 1905254) is a human/mouse/monkey cross-reactive antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2), blocks the immunosuppressive activity of ILDR2 for cancer immunotherapy.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Bapotulimab (BAY 1905254) is a human/mouse/monkey cross-reactive antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2), blocks the immunosuppressive activity of ILDR2 for cancer immunotherapy.
Bapotulimab (BAY 1905254) promotes T-cell activation in vitro and enhances antigen-specific T-cell proliferation and cytotoxicity in vivo in mice.
Bapotulimab (BAY 1905254) also showed potent efficacy in various syngeneic mouse cancer models. Bapotulimab (BAY 1905254) demonstrated synergistic antitumor effects in combination with anti-PD-L1, an immunogenic cell death-inducing chemotherapeutic, or with tumor antigen immunization.
Isotype: IgG2-kappa
Anti-[human ILDR2 (immunoglobulin like domain containing receptor 2,
C1orf32)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

参考文献

1. Julia Huetter, et al. Cancer Immunol Res. 2020 Jul;8(7):895-911.

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