Bapotulimab | Anti-ILDR2 mAb | Probechem Biochemicals

Chemical Structure : Bapotulimab

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Bapotulimab (BAY1905254)

货号: PC-38854Not For Human Use, Lab Use Only.

规格	价格	库存	数量
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Bapotulimab (BAY 1905254) is a human/mouse/monkey cross-reactive antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2), blocks the immunosuppressive activity of ILDR2 for cancer immunotherapy.
Bapotulimab (BAY 1905254) promotes T-cell activation in vitro and enhances antigen-specific T-cell proliferation and cytotoxicity in vivo in mice.
Bapotulimab (BAY 1905254) also showed potent efficacy in various syngeneic mouse cancer models. Bapotulimab (BAY 1905254) demonstrated synergistic antitumor effects in combination with anti-PD-L1, an immunogenic cell death-inducing chemotherapeutic, or with tumor antigen immunization.
Isotype: IgG2-kappa
Anti-[human ILDR2 (immunoglobulin like domain containing receptor 2,
C1orf32)], human monoclonal antibody.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Julia Huetter, et al. Cancer Immunol Res. 2020 Jul;8(7):895-911.

Bapotulimab (BAY1905254)

生物&药学活性

物理化学性质&存储条件

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Bapotulimab (BAY1905254)

生物&药学活性

物理化学性质&存储条件

参考文献

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