Bacterial SPase inhibitor MD3

Chemical Structure : Bacterial SPase inhibitor MD3

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货号: PC-25079Not For Human Use, Lab Use Only.

Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein.
MD3 inhibits recombinant Escherichia coli SPase (LepB).
MD3 demonstrates potent activity against wild-type and multidrug-resistant strains of A. baumannii and S. maltophilia with MICs ranging from 0.5 to 14 mg/L in the presence of subinhibitory concentrations of colistin.

物理化学性质&存储条件

分子量	246.13
分子式	C11H13Cl2NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one

参考文献

1. Personne Y, et al. J Antimicrob Chemother. 2014 Dec;69(12):3236-43.

2. Ollinger J, et al. J Bacteriol. 2012 May;194(10):2614-9.

3. Barbosa MD, et al. Antimicrob Agents Chemother. 2002 Nov;46(11):3549-54.