BZ194 | NAADP inhibitor | Probechem Biochemicals

Chemical Structure : BZ194

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BZ194 (BZ-194)

货号: PC-62061Not For Human Use, Lab Use Only.

BZ194 (BZ-194) is a small molecule inhibitor of NAADP action that inhibit NAADP-mediated Ca2+ signaling in T cells, neither interferes with Ca2+ mobilization by IP3 or cyclic ADP-ribose nor with capacitative Ca2+ entry.

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生物&药学活性

BZ194 (BZ-194) is a small molecule inhibitor of NAADP action that inhibit NAADP-mediated Ca2+ signaling in T cells, neither interferes with Ca2+ mobilization by IP3 or cyclic ADP-ribose nor with capacitative Ca2+ entry.
BZ194 specifically and effectively blocks NAADP-stimulated [3H]ryanodine binding to the purified type 1 ryanodine receptor.
BZ194 efficiently suppresses antigen-induced production of the major T cell cytokine IL-2.

物理化学性质&存储条件

分子量	373.291
分子式	C16H25BrN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-carboxy-1-(2-(octylamino)-2-oxoethyl)pyridin-1-ium bromide

参考文献

1. Dammermann W, et al. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83.

2. Cordiglieri C, et al. Brain. 2010 Jul;133(Pt 7):1930-43.

3. Nebel M, et al. J Biol Chem. 2013 May 31;288(22):16017-30.

4. Ali RA, et al. Cell Calcium. 2014 Feb;55(2):93-103.

BZ194 (BZ-194)

生物&药学活性

物理化学性质&存储条件

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BZ194 (BZ-194)

生物&药学活性

物理化学性质&存储条件

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