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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Nitric Oxide Synthase (NOS)-BYK191023
BYK191023

Chemical Structure : BYK191023

CAS No.: 608880-48-4

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BYK191023 (BYK-191023)

货号: PC-35418Not For Human Use, Lab Use Only.

BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM).
BYK191023 exhibits an affinity for iNOS, nNOS, and eNOS of 450 nM, 30 uM, and >500 uM, respectively.
BYK191023 inhibits cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells with IC50 values 40- to 100-fold higher than at the isolated enzyme.
BYK191023 dose-dependently suppresses the LPS-induced increase in plasma nitrate/nitrite (NO(x)) levels with ED50 of 14.9 micromol/kg/h, partially restores normal blood pressure responses to norepinephrine and sodium nitroprusside in model of LPS-induced vascular hyporesponsiveness.

物理化学性质&存储条件

分子量 254.293
分子式 C14H14N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine

参考文献

1. Strub A, et al. Mol Pharmacol. 2006 Jan;69(1):328-37.

2. Lehner MD, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):181-7.

3. Tiso M, et al. Mol Pharmacol. 2008 Apr;73(4):1244-53.

4. Higashi Y, et al. Br J Pharmacol. 2018 Jul 14. doi: 10.1111/bph.14445.

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