BXI-72 (NSC334072, Hoechst 33342) | BCL-XL inhibitor | Probechem Biochemicals

Chemical Structure : BXI-72

CAS No.: 23491-52-3

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BXI-72 (NSC334072, Bcl-XL inhibitor BXI-72, Hoechst 33342)

货号: PC-35590Not For Human Use, Lab Use Only.

BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM).

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25 mg	￥880	In stock
100 mg	￥1880	In stock
500 mg	￥4680	In stock
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生物&药学活性

BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM).
BXI-72 displays very low binding affinities with Bcl2 (Ki=283 nM), Mcl-1, Bcl-w and Bfl-1/A1 (Ki>1500 nM).
BXI-72 potently suppresses lung cancer cell growth (H1299=0.49 uM, A549 IC50=0.68 uM), displays relatively selective cytotoxicity against lung cancer cells compared to normal human bronchial epithelial cells.
BXI-72 causes disruption of Bcl-XL/Bak or Bcl-XL/Bax interaction, oligomerization of Bak, and cytochrome c release from mitochondria in cells.
BXI-72 exhibits more potent efficacy against human lung cancer than ABT-737 but less degree in platelet reduction in vivo.
BXI-72 (NSC334072, Hoechst 33342) is a marker dye in Hoechst series for live nuclear marker dye.

物理化学性质&存储条件

分子量	489.01
分子式	C27H29ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole

参考文献

1. Park D, et al. Cancer Res. 2013 Sep 1;73(17):5485-96.

2. Barrott JJ, et al. Mol Cancer Res. 2017 Dec;15(12):1733-1740.

BXI-72 (NSC334072, Bcl-XL inhibitor BXI-72, Hoechst 33342)

生物&药学活性

物理化学性质&存储条件

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BXI-72 (NSC334072, Bcl-XL inhibitor BXI-72, Hoechst 33342)

生物&药学活性

物理化学性质&存储条件

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