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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PDK1-BX795
BX795

Chemical Structure : BX795

CAS No.: 702675-74-9

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BX795 (BX 795, BX-795)

货号: PC-42629Not For Human Use, Lab Use Only.

BX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM.
BX795 also inhibits TBK1 and IKKε with IC50 of 6 nM and 41 nM.
BX795 shows no activity for PKA, PKC, c-Kit, GSK3β, IKKα, IKKβ, etc.
BX795 blocks the autophosphorylation of overexpressed TBK1 and IKKepsilon at Ser-172.
BX795 has no effect on the canonical NFkappaB signaling pathway.

物理化学性质&存储条件

分子量 591.4677
分子式 C23H26IN7O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Pyrrolidinecarboxamide, N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-

参考文献

1. Clark K, et al. J Biol Chem. 2009 May 22;284(21):14136-46.

2. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.

3. Frémond ML, et al. Arthritis Rheumatol. 2017 Apr 20. doi: 10.1002/art.40122.

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