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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PDK1-BX-912
BX-912

Chemical Structure : BX-912

CAS No.: 702674-56-4

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BX-912 (BX912, BX 912)

货号: PC-42781Not For Human Use, Lab Use Only.

BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.

物理化学性质&存储条件

分子量 471.3536
分子式 C20H23BrN8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-

参考文献

1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.

2. Mashukova A, et al. Mol Biol Cell. 2012 May;23(9):1664-74.

3. Sturm EM, et al. Eur J Immunol. 2015 May;45(5):1548-59.

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