BX-320 | PDK1 inhibitor | Probechem Biochemicals

Chemical Structure : BX-320

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BX-320 (BX320)

货号: PC-63030Not For Human Use, Lab Use Only.

BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA.

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生物&药学活性

BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA.
BX-320 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.
BX-320 inhibits the growth of LOX melanoma tumors in the lungs of nude mice.

物理化学性质&存储条件

分子量	547.458
分子式	C23H31BrN8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Propanediamide, N-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethyl- (9CI)

参考文献

1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.

BX-320 (BX320)

生物&药学活性

物理化学性质&存储条件

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BX-320 (BX320)

生物&药学活性

物理化学性质&存储条件

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