BVL3572S

Chemical Structure : BVL3572S

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货号: PC-27995Not For Human Use, Lab Use Only.

BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis.

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生物&药学活性

BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis.
BVL3572S shows broad-spectrum activity against Gram-positive and Gram-negative bacteria.
BVL3572S inhibits Mtb growth by targeting histidine and alanine biosynthesis, has a broad impact on intrabacterial amino acid levels.
BVL3572S synergizes with the second-line antibiotic D-cycloserine.

物理化学性质&存储条件

分子量	257.09
分子式	C9H9BrN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-Amino-7-bromo-3,4-dihydro-1-hydroxy-2(1H)-quinolinone

参考文献

1. Zainab Edoo, et al. Cell Chem Biol. 2026 Aug 11:S2451-9456(26)00281-3.

BVL3572S

生物&药学活性

物理化学性质&存储条件

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BVL3572S

生物&药学活性

物理化学性质&存储条件

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