BVL-GSK098 (Alpibectir) | M.tb VirS inhibitor | Probechem Biochemicals

Chemical Structure : BVL-GSK098

CAS No.: 2285440-39-1

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BVL-GSK098 (Alpibectir, BVL-GSK 098)

货号: PC-49179Not For Human Use, Lab Use Only.

BVL-GSK098 (Alpibectir) is a small molecule able to inhibit Mycobacterium tuberculosis transcription regulator VirS, boosts bioactivation of ethionamide (ETH) and lower ETH MIC.

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

BVL-GSK098 (Alpibectir) is a small molecule able to inhibit Mycobacterium tuberculosis transcription regulator VirS, boosts bioactivation of ethionamide (ETH) and lower ETH MIC.
BVL-GSK098 (Alpibectir) activates an EthA-independent-, VirS-dependent bioactivation pathway of ETH, makes ETH-resistant Mtb again susceptible to low ETH concentrations.

物理化学性质&存储条件

分子量	332.246
分子式	C12H14F6N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4,4-trifluoro-1-(3-(trifluoromethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one

参考文献

1. Patent WO2019034700 A1 2019-02-21.

BVL-GSK098 (Alpibectir, BVL-GSK 098)

生物&药学活性

物理化学性质&存储条件

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BVL-GSK098 (Alpibectir, BVL-GSK 098)

生物&药学活性

物理化学性质&存储条件

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