BU09059 | KOR antagonist | Probechem Biochemicals

Chemical Structure : BU09059

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BU09059 (BU 09059, BU-09059)

货号: PC-35296Not For Human Use, Lab Use Only.

BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively.

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生物&药学活性

BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively.
BU09059 is a potent and selective κ-antagonist with pA2 of 8.62, significantly blocks U50,488-induced antinociception in vivo (3 and 10 mg/kg).
BU09059 demonstrates a shorter duration of κ-antagonist action in vivo.

物理化学性质&存储条件

分子量	495.62
分子式	C28H37N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-{[(3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]formamido}-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoate

参考文献

1. Casal-Dominguez JJ, et al. Send to ACS Chem Neurosci. 2014 Mar 19;5(3):177-84.

BU09059 (BU 09059, BU-09059)

生物&药学活性

物理化学性质&存储条件

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BU09059 (BU 09059, BU-09059)

生物&药学活性

物理化学性质&存储条件

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