BTdCPU

Chemical Structure : BTdCPU

CAS No.: 1257423-87-2

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货号: PC-26552Not For Human Use, Lab Use Only.

BTdCPU is a potent activator of heme-regulated inhibitor (HRI) eIF2α kinase that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone-resistant cancer cells.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

BTdCPU is a potent activator of heme-regulated inhibitor (HRI) eIF2α kinase that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone-resistant cancer cells.
BTdCPU treatment induced phosphorylation of eIF2α and and upregulated mRNA and protein levels of the pro-apoptotic protein CHOP in Dex-resistant (MM1.R, RPMI 8266, U266) MM cells.
BTdCPU is cytotoxic for dex-resistant primary MM cells with relative sparing of normal cells.
BTdCPU triggers MCL-1 repression and synergizes with BH3-mimetics in mouse and human leukemia including both Ph+ and Ph-like B-ALL.

物理化学性质&存储条件

分子量	339.19
分子式	C13H8Cl2N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea

参考文献

1. Smith KH, et al. Mol Cancer Res. 2021 Apr;19(4):636-650.

2. Burwick N, et al. Leuk Res. 2017 Apr;55:23-32.

BTdCPU

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BTdCPU

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