BTT-877 | Autotaxin inhibitor | Probechem Biochemicals

Chemical Structure : BTT-877

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BTT-877 (BTT877)

货号: PC-49584Not For Human Use, Lab Use Only.

BTT-877 (BTT877) is a potent, selective and orally active inhibitor of autotaxin (ENPP2) with in vitro and ex vivo IC50 of 2.4 nM and 6.89 nM, respectively.

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生物&药学活性

BTT-877 (BTT877) is a potent, selective and orally active inhibitor of autotaxin (ENPP2) with in vitro and ex vivo IC50 of 2.4 nM and 6.89 nM, respectively.
BTT-877 potently inhibits LPA-induced cell migtation, suppresses inflammation and sclerosis by reducing LPA production through the selective inhibition of autotaxin.
BTT-877 demonstrated in vivo anti-fibrotic efficacy in the mouse model of bleomycin-induced pulmonary fibrosis.

物理化学性质&存储条件

分子量	443.47
分子式	C22H21N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[5-[2-[(2,3-Dihydro-1H-inden-2-yl)amino]-5-pyrimidinyl]-1,3,4-oxadiazol-2-yl]-1-(3,4,6,7-tetrahydro-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl)ethanone

BTT-877 (BTT877)

生物&药学活性

物理化学性质&存储条件

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BTT-877 (BTT877)

生物&药学活性

物理化学性质&存储条件

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