BTT-369 | Probechem Biochemicals

Chemical Structure : BTT-369

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BTT-369 (BTT 369;BTT 369)

货号: PC-35727Not For Human Use, Lab Use Only.

BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays.

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生物&药学活性

BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays.
BTT-369 decreases trafficking of CaV2.2 channels to the plasma membrane and modulates the functions of the channel, suppresses pain responses in rodent neuropathic pain models.
BTT-369 (BTT369) is a cell-permeable derivative of BTT-266.

物理化学性质&存储条件

分子量	580.652
分子式	C34H28N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-(1H-tetrazol-5-yl)phenyl)(5-(4-methoxyphenyl)-1'-phenyl-3'-(p-tolyl)-3,4-dihydro-1'H,2H-[3,4'-bipyrazol]-2-yl)methanone

参考文献

1. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10566-E10575.

BTT-369 (BTT 369;BTT 369)

生物&药学活性

物理化学性质&存储条件

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BTT-369 (BTT 369;BTT 369)

生物&药学活性

物理化学性质&存储条件

参考文献

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