BTT-266 |2413939-89-4 Probechem Biochemicals

Chemical Structure : BTT-266

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BTT-266 (BTT266;BTT 266)

货号: PC-35726Not For Human Use, Lab Use Only.

BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM.

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生物&药学活性

BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM.
BTT-266 decreases surface presentation of the CaV2.2α1 subunit, significantly reduces trafficking of CaV2.2 to the plasma membrane at 50 uM.
BTT-266 does not affect CaV2.2 currents in either in HEK-CaV2.2 cells or rat dorsal root ganglion (DRG) neurons.

物理化学性质&存储条件

分子量	556.622
分子式	C34H28N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(4-methoxyphenyl)-1'-phenyl-3'-(p-tolyl)-3,4-dihydro-1'H,2H-[3,4'-bipyrazole]-2-carbonyl)benzoic acid

参考文献

1. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Oct 24. pii: 201813157.

BTT-266 (BTT266;BTT 266)

生物&药学活性

物理化学性质&存储条件

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BTT-266 (BTT266;BTT 266)

生物&药学活性

物理化学性质&存储条件

参考文献

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