BTRX-335140 | KOR antagonist | Probechem Biochemicals

Chemical Structure : BTRX-335140

CAS No.: 2244614-14-8

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BTRX-335140 (Navacaprant, CYM-53093, BTRX335140, CYM53093)

货号: PC-36056Not For Human Use, Lab Use Only.

BTRX-335140 (Navacaprant, CYM-53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BTRX-335140 (Navacaprant, CYM-53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM.
BTRX-335140 displays >100-fold selectivity over MOR and DOR.
BTRX-335140 demonstrates favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments, shows robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice.

物理化学性质&存储条件

分子量	453.562
分子式	C25H32FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4 amine

参考文献

1. Guerrero M, et al. J Med Chem. 2019 Feb 1. doi: 10.1021/acs.jmedchem.8b01679.

BTRX-335140 (Navacaprant, CYM-53093, BTRX335140, CYM53093)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BTRX-335140 (Navacaprant, CYM-53093, BTRX335140, CYM53093)

生物&药学活性

物理化学性质&存储条件

参考文献

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