BTK-IN-23 |CAS:1227206-13-4 Probechem Biochemicals

Chemical Structure : BTK-IN-23

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BTK-IN-23 (BTK inhibitor 23)

货号: PC-62701Not For Human Use, Lab Use Only.

BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.
BTK-IN-23 displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK.
BTK-IN-23 demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM.
BTK-IN-23 shows improved stability compared to GDC-0834.

物理化学性质&存储条件

分子量	529.594
分子式	C27H24FN7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-fluoro-2-methyl-3-(5-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)benzo[b]thiophene-2-carboxamide

参考文献

1. Young WB, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-9.

BTK-IN-23 (BTK inhibitor 23)

生物&药学活性

物理化学性质&存储条件

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BTK-IN-23 (BTK inhibitor 23)

生物&药学活性

物理化学性质&存储条件

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