BTI-A-404

Chemical Structure : BTI-A-404

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货号: PC-24797Not For Human Use, Lab Use Only.

BTI-A-404 is a selective and potent competitive inverse agonist / antagonist of human GPR43 (FFA2R) with cAMP IC50 of 9.5 uM.

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生物&药学活性

BTI-A-404 is a selective and potent competitive inverse agonist / antagonist of human GPR43 (FFA2R) with cAMP IC50 of 9.5 uM.
BTI-A-404 increased intracellular level of cAMP (IC50=9.5 uM) and reversed the effect of propionate on cAMP production only in the presence of hGPR43 in Glosensor cell line, but not in Glosensor cells without hGPR43.
BTI-A-404 is still able to increase cAMP with both of IC50 of 2.1 μM only in the GPR43-overexpressing cells.
BTI-A-404 is inactive against hGPR41 and hChemR23 at concentrations up to 50 μM, also does not inhibits mGPR43.
BTI-A-404 significantly induced the secretion of GLP-1 in NCI-H716 cells.

物理化学性质&存储条件

分子量	378.48
分子式	C22H26N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide

参考文献

1. Park BO, et al. Eur J Pharmacol. 2016 Jan 15;771:1-9.

BTI-A-404

生物&药学活性

物理化学性质&存储条件

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BTI-A-404

生物&药学活性

物理化学性质&存储条件

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