BTI (BrpT Inhibitor)

Chemical Structure : BTI (BrpT Inhibitor)

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货号: PC-23291Not For Human Use, Lab Use Only.

BTI (BrpT Inhibitor) is a specific small molecule inhibitor of V. vulnificus transcriptional regulator BrpT with EC50 of 6.48 uM, without affecting bacterial growth or host cell viability.

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生物&药学活性

BTI (BrpT Inhibitor) is a specific small molecule inhibitor of V. vulnificus transcriptional regulator BrpT with EC50 of 6.48 uM, without affecting bacterial growth or host cell viability.
BTI significantly reduced the expression of the BrpT regulon and impaired biofilm formation and colony rugosity in V. vulnificus, thus increasing its susceptibility to antibiotics.
BTI directly binds to BrpT and inhibits its transcriptional regulatory activity.
BTI effectively diminishes V. vulnificus biofilm formation

物理化学性质&存储条件

分子量	272.32
分子式	C14H12N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2-(5-methylfuran-2-yl)thiazol-4-yl)methyl)pyridin-2(1H)-one

参考文献

1. Choi W, et al. J Microbiol Biotechnol. 2024 Sep 20;34(11):1-10.