BTFA

Chemical Structure : BTFA

CAS No.: 328-74-5

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货号: PC-27056Not For Human Use, Lab Use Only.

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50 mg	￥1980	In stock
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生物&药学活性

BTFA is a specific small molecule P2X1 receptor inhibitor, binds to the top of the central vestibule and inhibits cation flux in a dose-dependent manner, inhibits the mixed-cation current of the mP2X1 receptor with IC50 of 4.3 uM.
BTFA also suppresses ATP-induced Ca2+ influx in HEK293 cells overexpressing mP2X1.
BTFA does not induce closure of the P2X1 channel, unlike NF449, which triggers extracellular conformational rearrangements and restores the transmembrane domain to a closed state.
BTFA has no effect on the human P2X2 and human P2X7 receptors, also with minimal inhibitory effects on the human P2X3 receptor.
BTFA binds to the extracellular domain without inducing detectable conformational changes in the extracellular region.

物理化学性质&存储条件

分子量	229.13
分子式	C8H5F6N
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-bis(trifluoromethyl)aniline

参考文献

1. Zhang H, et al. Cell Discov. 2026 Jun 4;12(1):41.

BTFA

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物理化学性质&存储条件

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