BTC-8 | Probechem Biochemicals

Chemical Structure : BTC-8

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BTC-8 (BTC 8;BTC8)

货号: PC-60923Not For Human Use, Lab Use Only.

BTC-8 is a derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

BTC-8 is a derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.
BTC-8 inhibits GBM cell proliferation, arrests the cell cycle, and induces apoptosis through the induction of mitochondrial membrane permeabilization.
BTC-8 also blocks proliferation and self-renewal of GSCs and induces their apoptosis; sensitizes both GBM cells and GSCs to the alkylating agent Temozolomide.

物理化学性质&存储条件

分子量	457.534
分子式	C26H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(4'-(dimethylamino)-2-hydroxy-[1,1'-biphenyl]-4-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

参考文献

1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114.

2. Stornaiuolo M, et al. J Med Chem. 2015 Mar 12;58(5):2135-48.

BTC-8 (BTC 8;BTC8)

生物&药学活性

物理化学性质&存储条件

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BTC-8 (BTC 8;BTC8)

生物&药学活性

物理化学性质&存储条件

参考文献

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