BTB-1 | Kif18A inhibitor | Probechem Biochemicals

Chemical Structure : BTB-1

CAS No.: 86030-08-2

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BTB-1 (Kif18A inhibitor BTB-1)

货号: PC-49285Not For Human Use, Lab Use Only.

BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.

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25 mg	￥1480	In stock
50 mg	￥2580	In stock
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生物&药学活性

BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
BTB-1 decreased the expression of viral RNAs and proteins, and the production of infectious viral particles, while overexpression of KIF18A enhanced the replication of influenza A virus (IAV).
BTB-1 treatment attenuated the activation of AKT, p38 MAPK, SAPK and Ran-binding protein 3 (RanBP3), which led to the prevention of the nuclear export of viral ribonucleoprotein complexes.
BTB-1 greatly improved the viability of IAV-infected mice.
BTB-1 treatment strongly inhibited the differentiation of mouse bone marrow (BM) cells into dendritic cells (DCs) in a dose-dependent manner.
Treatment of immature DCs with BTB-1 significantly impaired the expression of activation markers on DCs including MHC class I, CD80, and CD86 upon TLR4 or TLR7 treatment.

物理化学性质&存储条件

分子量	297.72
分子式	C12H8ClNO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

参考文献

1. Braun J, et al. ACS Chem Biol. 2015 Feb 20;10(2):554-60.

2. Catarinella M, et al. Angew Chem Int Ed Engl. 2009;48(48):9072-6.

3. Locke J, et al. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548.

4. Cho YB, et al. J Cell Mol Med. 2020 May;24(10):5463-5475.

BTB-1 (Kif18A inhibitor BTB-1)

生物&药学活性

物理化学性质&存储条件

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BTB-1 (Kif18A inhibitor BTB-1)

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物理化学性质&存储条件

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