BT2 | Angiogenesis inhibitor | Probechem Biochemicals

Chemical Structure : BT2

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BT2 (MEK1 inhibitor)

货号: PC-38417Not For Human Use, Lab Use Only.

BT2 is a thermostable small-molecule inhibitor of vascular permeability and angiogenesis, interacts with MEK1 and inhibits ERK phosphorylation, FosB/ΔFosB, and VCAM-1 expression.

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生物&药学活性

BT2 is a thermostable small-molecule inhibitor of vascular permeability and angiogenesis, interacts with MEK1 and inhibits ERK phosphorylation, FosB/ΔFosB, and VCAM-1 expression.
BT2 blocks endothelial FosB/ΔFosB expression, proliferation, migration and wound repair after in vitro injury and network formation.
BT2 also inhibited a range of other regulatory genes involved in cell proliferation, migration, angiogenesis, and inflammation including intercellular adhesion molecule-1 (ICAM-1), CXCL2, KLF5, Egr-1, and Fos.
BT2 reduced retinal leakage in rats at least as effectively as aflibercept, a first-line therapy for nAMD/DR.

物理化学性质&存储条件

分子量	326.352
分子式	C18H18N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (10-ethyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepin-2-yl)carbamate

参考文献

1. Yue Li, et al. Sci Adv. 2020 Jul 29;6(31):eaaz7815.

BT2 (MEK1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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BT2 (MEK1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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