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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-BT173
BT173

Chemical Structure : BT173

CAS No.: 2232180-74-2

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BT173 (BT-173)

货号: PC-73293Not For Human Use, Lab Use Only.

BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway.
BT173 disrupts HIPK2-Smad3 protein-protein interaction (PPI) without significant inhibition of HIPK2 kinase activity or inhibition of p53 activation.
BT173 inhibits Smad3 phosphorylation in human kidney cells in vitro.
BT173 significantly attenuated renal fibrosis development in the UUO mice, significantly decreased Smad3 phosphorylation and α-SMA expression in the UUO kidneys.
Treatment of BT173 ameliorated kidney fibrosis in Tg26 mice.

物理化学性质&存储条件

分子量 382.217
分子式 C18H12BrN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Quinoline, 3-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]-7-methoxy-

参考文献

1. Liu R, et al. J Am Soc Nephrol. 2017 Jul;28(7):2133-2143.

2. Caescu CI, et al. Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2483-2493.

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