BT-13 | RET agonist | Probechem Biochemicals

Chemical Structure : BT-13

CAS No.: 924537-98-4

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BT-13 (RET agonist BT13)

货号: PC-61589Not For Human Use, Lab Use Only.

RET agonist BT13 is a novel small molecule GDNF receptor RET agonist, potently and selectively activates RET and its downstream intracellular signaling cascades in immortalized cells (EC50~20 uM).

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

RET agonist BT13 (BT-13) is a novel small molecule GDNF receptor RET agonist, potently and selectively activates RET and its downstream intracellular signaling cascades in immortalized cells (EC50~20 uM)>
RET agonist BT13 promotes neurite outgrowth from cultured dorsal root ganglia (DRG) sensory neurons in vitro.
RET agonist BT13 alleviates mechanical hypersensitivity and reverses injury-induced changes in protein expression in DRG neurons in rat model of neuropathic pain.

物理化学性质&存储条件

分子量	517.54
分子式	C23H27F4N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-diethyl-3-(4-(4-fluoro-2-(trifluoromethyl)benzoyl)piperazin-1-yl)-4-methoxybenzenesulfonamide

参考文献

1. Sidorova YA, et al. Front Pharmacol. 2017 Jun 21;8:365.

BT-13 (RET agonist BT13)

生物&药学活性

物理化学性质&存储条件

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BT-13 (RET agonist BT13)

生物&药学活性

物理化学性质&存储条件

参考文献

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