BS-194 |CAS:1092443-55-4 Probechem Biochemicals

Chemical Structure : BS-194

CAS No.: 1092443-55-4

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BS-194 (BS 194;BS194)

货号: PC-61917Not For Human Use, Lab Use Only.

BS-194 (BS194) is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

BS-194 (BS194) is a potent, selective, orally bioactive CDK2 inhibitor with IC50 of 2.4 nM, displays 140-fold selectivity over CDK7 (IC50=378 nM).
BS-194 weakly inhibits CDK1, CDK5, CDK7, and CDK9 with IC50 of 30, 30, 250, and 90 nM.
BS-194 shows inhibition of the phosphorylation of CDK substrates, Rb and the RNA polymerase II C-terminal domain, down-regulation of cyclins A, E, and D1, and cell cycle block in the S and G2/M phases.
BS-194 inhibits human tumor xenografts and suppresses CDK substrate phosphorylation.

物理化学性质&存储条件

分子量	385.468
分子式	C20H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-3-[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol

参考文献

1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.

2. Tripathi SK, et al. J Mol Recognit. 2012 Oct;25(10):504-12.

3. Heathcote DA, et al. J Med Chem. 2010 Dec 23;53(24):8508-22.

BS-194 (BS 194;BS194)

生物&药学活性

物理化学性质&存储条件

参考文献

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BS-194 (BS 194;BS194)

生物&药学活性

物理化学性质&存储条件

参考文献

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