BRK inhibitor P21d | PTK6 inhibitor | Probechem Biochemicals

Chemical Structure : BRK inhibitor P21d

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BRK inhibitor P21d (PTK6 inhibitor P21d)

货号: PC-35189Not For Human Use, Lab Use Only.

BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM).
BRK inhibitor P21d exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells.
BRK inhibitor P21d suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation.

物理化学性质&存储条件

分子量	447.474
分子式	C23H22FN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)-3-fluorophenyl)(morpholino)methanone

参考文献

1. Zeng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5.

2. Ito K, et al. Cancer Res. 2016 Aug 1;76(15):4406-17.

BRK inhibitor P21d (PTK6 inhibitor P21d)

生物&药学活性

物理化学性质&存储条件

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BRK inhibitor P21d (PTK6 inhibitor P21d)

生物&药学活性

物理化学性质&存储条件

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