BRGi-39 | BRG1 inhibitor | Probechem Biochemicals

Chemical Structure : BRGi-39

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BRGi-39 (Z448047898)

货号: PC-27182Not For Human Use, Lab Use Only.

BRGi-39 (Z448047898) is a selective inhibitor of switch/sucrose non-fermentable (SWI/SNF) complex core ATPase subunit BRG1, blocks BRG1-BRD with exceptional selectivity and high affinity.

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生物&药学活性

BRGi-39 (Z448047898) is a selective inhibitor of switch/sucrose non-fermentable (SWI/SNF) complex core ATPase subunit BRG1, blocks BRG1-BRD with exceptional selectivity and high affinity.
BRGi-39 (10 uM) does not significantly inhibit HCC cell proliferation at low doses.
BRGi-39 sensitizes HCC cells to irradiation by augmenting the G2/M arrest and apoptosis, disrupts DDR in irradiated HCC cells.
BRGi-39 sensitizes HCC cells to chemotherapeutic drugs by inhibiting DSB repair.
BRGi-39 sensitizes xenografted liver cancer to chemoradiotherapy.

物理化学性质&存储条件

分子量	334.42
分子式	C20H22N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-amino-1H-indazol-1-yl)(4-(piperidin-1-ylmethyl)phenyl)methanone

参考文献

1. Qing Tao, et al. Chin Med J (Engl). 2026 Jun 24. doi: 10.1097/CM9.0000000000004123.

BRGi-39 (Z448047898)

生物&药学活性

物理化学性质&存储条件

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BRGi-39 (Z448047898)

生物&药学活性

物理化学性质&存储条件

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